Sodium Bicarbonate → HCID 70171511, compound

Participants

Reaction Steps

(S)-N-{1-[2-Bromo-7-(tert-butyldimethylsilyloxy)naphthalen-1-yl]-2-oxopyrrolidin-3-yl}-2-[1-(4-cyano-3-fluorobenzyl)-1H-imidazol-5-yl]acetamide, as described above in Step K, (171 mg, 0.264 mmol) was dissolved in THF (5 mL) and TBAF (1.0 M in THF, 0.26 mL, 0.26 mmol) was added. After 45 min, the mixture was poured into saturated aqueous NaHCO3 and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and concentrated in vacuo. The residue was chromatographed on silica gel, eluting with a gradient of CH2Cl2—1% to 10% MeOH—0.1% to 1% NH4OH, to yield the above-titled compound.

Provenance & Evidence