HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 6-Hydroxy-chroman-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 6-methoxy-3,4-dihydro-2H-1-benzopyran-4-one | HCID 4612168 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 6-Hydroxy-chroman-4-one | HCID 7098944 | — |
Reaction Steps
A solution of 6-methoxy-2,3-dihydro-4H-chromen-4-one in 48% aqueous HBr (250 mL) and HOAc (250 mL) was heated to 75° C. for 6 hours. The reaction mixture was cooled, adjusted to pH≈5 by the addition of saturated aqueous Na2CO3 and extracted with CHCl3 (2×75 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated in vacuo to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06441017B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-39cdfb81a635443ba685088b485d0806 |
| Source note | uspto-grants-2002_08 |