HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexamethylditin → 2-Acetoxymethyl-4-(trimethylstannyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexamethylditin | HCID 6327618 | — |
| Reactant | 2-Acetoxymethyl-4-bromothiazole | HCID 18761616 | — |
| Reactant | 2-Piperidinyl(trimethylstannyl)thiazole | HCID 59118286 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Acetoxymethyl-4-(trimethylstannyl)thiazole | HCID 18761603 | — |
Reaction Steps
2-Acetoxymethyl-4-bromothiazole (387) was taken up in degassed toluene (0.1 M), and was then treated hexamethylditin (10 equiv) and tetrakis(triphenylphosphine)palladium(0) (0.1 equiv) at 80° C. for 3 h according to the procedure described for the synthesis of 2-piperidinyl-4-(trimethylstannyl)thiazole (373), to yield, after flash column chromatography (silica gel, 5% NEt, in hexanes), 2-dacetoxymethyl-4-(trimethylstannyl)thiazole (388; 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06441186B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-b7e3ceff3620405aa946bbfd4175438a |
| Source note | uspto-grants-2002_08 |