4-Bromobenzoyl chloride → HCID 18434326, compound

Participants

Reaction Steps

350 mg of N-methyl-2-biphenylyl-pyrrolidine hydrochloride are suspended in 10 ml of carbon disulphide and treated with 341 mg of aluminium chloride. A solution of 842 mg of 4-bromo-benzoyl chloride in 3 ml of carbon disulphide is added dropwise to this viscous mass. The mixture is held at reflux for 2 hours and evaporated. The residue is triturated in toluene and then in ethyl acetate, with 90 mg of (±)(4-bromophenyl)-[4′-(1-methylpyrrolidin-2-yl)-biphenyl-4-yl]-methanone•hydrochloride, m.p. 225° C., being obtained.

Provenance & Evidence