Iodoethane → HCID 69817507, compound

Participants

Reaction Steps

5-Nitro-2,3,3-trimethylindole (518 mg, 2.54 mmol) and ethyl iodide (2.5 ml, 4.85 g, 31 mmol, excess) were mixed and heated to reflux for 8 hours. After cooling to room temperature the excess ethyl iodide was removed by a gentle nitrogen stream and the residue was dissolved in chloroform and filtered through a plug of silica. The silica was washed with chloroform (1 volume) and the combined filtrates were rotary evaporated to give the product as a yellow oil, (486 mg, 1.35 mmol, 53% yield).

Provenance & Evidence