HCID 22609270, compound → HCID 22609235, compound

Participants

Reaction Steps

In a 20 ml balloon flask, we resuspend 0.2 g (0.46 mmol) of 7-acetamido-4-[(E)-3-phenylallyl]-1-(pyrrolidin-1-yl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one (describe example 222) in 5 ml of 6N hydrochloric acid solution and heat by reflux, under shaking, for 15 minutes. After cooling down, the obtained solution is alkalinized by soda solution, extracted 3 times by methylene chloride. The joined organic phases are washed with a NaCl-saturated solution, dried on Na2SO4 then evaporated under vacuum. The crude product (0.12 g) is recrystallized in ethanol to give 0.08 g of the pure compound from example 223.

Provenance & Evidence