Cyclopropanecarboxylic acid → HCID 10194166, compound

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Reaction Steps

Prepared from 2-[4-(5(S)-aminomethyl-2-oxo-oxazolidin-3-yl)-2-fluorophenyl]-4H-[1,3,4]thiadiazin-5-one (0.30 g, 0.925 mmol and cyclopropanecarboxylic acid (0.0812 ml, 1.02 mmol) according to the method of Example 15 (0.30 g, 84%); 1HNMR (300 MHz, DMSO-d6) δ 0.59-0.68 (m, 4H), 1.53-1.62 (m, 1H), 3.44 (t, J=5.2 Hz, 2H), 3.58 (s, 2H), 3.72 (dd, J=6.3, 9.1 Hz, 1H), 4.14 (t, J=9.1 Hz, 1H), 4.72-4.78 (m, 1H), 7.41 (dd, J=2.2, 8.5 Hz, 1H), 7.53 (dd, J=2.2, 14 Hz, 1H), 7.68 (t, J=8.8 Hz, 1H), 8.46 (t, J=5.8 Hz, 1H), 11.6 (s, 1H); mp 239-40; MS (m/z): [M+H]+=393.

Provenance & Evidence