Lawesson's reagent → HCID 10288183, compound

Participants

Reaction Steps

Lawesson's reagent (0.0715 g, 0.177 mmol) and {3-[3-fluoro-4-(5-oxo-5,6-dihydro-4H-[1,3,4]thiadiazin-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamic acid tert-butyl ester (0.100 g, 0.236 mmol) in dioxane (5 ml) are heated at 65° C. for 6 hours. The reaction mixture is evaporated to dryness and the residue is purified by PTLC (10% MeOH/DCM) to give bright yellow solid (0.088 g, 85%); 1HNMR (300 MHz, DMSO-d6) δ 1.34 (s, 9H), 3.28 (t, J=5.5 Hz, 2H), 3.82 (dd, J=6.0, 9.1 Hz, 1H), 4.01 (s, 2H), 4.14 (t, J=9.3 Hz, 1H), 4.70-4.78 (m, 1H), 7.24 (t, J=5.8 Hz, 1H), 7.45 (dd, J=2.2, 8.8 Hz, 1H), 7.60 (dd, J=2.2, 14 Hz, 1H), 7.73 (t, J=8.8 Hz, 1H), 8.07 (t, J=6.0 Hz, 1H); mp 134-6; MS (m/z): [M+H]+=441.

Provenance & Evidence