N-Methylbenzeneethanamine → N-methyl-N-(2-phenylethyl)-2-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}acetamide

Participants

Role	Name	HCID	Charge
Reactant	N-Methylbenzeneethanamine	HCID 11503	—
Reactant	{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}acetic acid	HCID 50992931	—
Product	N-methyl-N-(2-phenylethyl)-2-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}acetamide	HCID 24827049	—

Reaction Steps

The title compound was prepared from {4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}acetic acid and N-methylphenethylamine using a similar procedure to that described for Example 13, but purified by flash column chromatography eluting from 0-88% ethyl acetate in hexane, followed by mass directed auto-prep.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07566735B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-93a01032be5e4ce18f532c9d581cf9b8
Source note	uspto-grants-2009_07