Ammonium Chloride → HCID 178518710, compound

Participants

Reaction Conditions

Reaction Steps

6-Cyanoquinazolin-4-one (0.5 g) in dimethylformamide (5 ml) was treated with ammonium chloride (0.33 g) and sodium azide (0.38 g) and heated at 100° C. under nitrogen for 45 minutes. The resulting mixture was cooled, diluted with ethyl acetate and filtered. The filter cake was washed with dimethylformamide and ethyl acetate to give the title compound (0.56 g) as a cream solid; δH [2H6]DMSO 13.00(1H, bs), 8.70(1H, d), 8.40(1H, dd), 8.38(1H, bs), 8.05(1H, s), 7.68(1H, d); m/z (M−1+) 213.

Provenance & Evidence