HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzyloxyaniline → (4-Benzyloxyphenyl)-(6-iodoquinazolin-4-yl)-amine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzyloxyaniline | HCID 22860 | — |
| Reactant | 4-Chloro-6-iodoquinazoline | HCID 11173809 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (4-Benzyloxyphenyl)-(6-iodoquinazolin-4-yl)-amine Hydrochloride | HCID 21951949 | 97.4% |
Reaction Steps
4-Chloro-6-iodoquinazoline (8 g) was treated with 4-benzyloxyaniline (5.5 g) in acetonitrile (500 ml) at reflux under N2 for 18 hours. Subsequent cooling and filtration gave the title compound (13.13 g); m/z (M+1)+ 454.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06828320B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-9602f24766a7425e90c5240b5cec4269 |
| Source note | uspto-grants-2004_12 |