反应详情

(4-Benzyloxy-phenyl)-(6-iodoquinazolin-4-yl)-amine (1.2 g) in dioxane (10 ml) under N2 was treated with tributyltin cyanide (0.79 g) and catalytic quantities of 1.4-bis-(diphenylphosphino)-butane palladium (II) chloride and tetrakis (triphenylphosphine) palladium at reflux for 23 hours. The mixture was absorbed onto silica and chromatographed to give the title compound (0.65 g); δH [2H6]DMSO 10.01(1H, s), 9.14(1H, s), 8.63(1H, s), 8.15(1H, d), 7.87(1H, d), 7.73(2H, d), 7.45(5H, m), 7.10(2H, d), 5.13(2H, s); m/z (M+1)+ 353.

1. temperatureat reflux for 23 hours
2. customThe mixture was absorbed onto silica
3. customchromatographed