Triethyl orthoacetate → HCID 135703880, compound

HRID 2306703Notes

Reaction equation

HRID 2306703 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([NH:14][NH2:15])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:16](OCC)(OCC)(OCC)[CH3:17]>>[CH3:16][C:17]1[O:13][C:12]([C:8]2[CH:7]=[C:6]3[C:11]([C:2](=[O:1])[NH:3][CH:4]=[N:5]3)=[CH:10][CH:9]=2)=[N:14][N:15]=1

Participants

3

Reactant 2

HCID 66221Triethyl orthoacetateHCID 178514413HCID 178514413, compound

Product 1

HCID 135703880HCID 135703880, compound

Procedure

4-Hydroxy quinazoline-7-hydrazide (0.41 g) was treated with triethyl orthoacetate (10 ml) at reflux under nitrogen for 24 hours. The mixture was cooled, filtered and purified by chromatography to give the title compound (0.09 g); m/z (M+1+) 229.

Workup

  1. temperatureat reflux under nitrogen for 24 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-83f9acb7374d48189c780fa8fbda86f8
Source dataset
uspto-grants-2004_12
Patent number
US06828320B2

Reaction notes

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