4-(2-Fluoro-benzyloxy)-phenylamine → (4-(2-Fluoro-benzyloxy)-phenyl)-(6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine hydrochloride

HRID 2306731Notes

Reaction equation

HRID 2306731 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][O:5][C:6]1[CH:12]=[CH:11][C:9]([NH2:10])=[CH:8][CH:7]=1.[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([C:28]3[O:29][C:30]([C:33]([F:36])([F:35])[F:34])=[N:31][N:32]=3)[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:17].[F:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][O:5][C:6]1[CH:12]=[CH:11][C:9]([NH:10][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[O:29][C:30]([C:33]([F:36])([F:34])[F:35])=[N:31][N:32]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 176080564-(2-Fluoro-benzyloxy)-phenylamineHCID 226097564-Chloro-6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)quinazoline

Product 1

HCID 22609711(4-(2-Fluoro-benzyloxy)-phenyl)-(6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine hydrochloride

Procedure

The title compound was prepared according to Procedure A from 4-(2-fluoro-benzyloxy)aniline and 4-chloro-6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazoline; δH [2H6]DMSO 11.80(1H, bs), 9.54(1H, s), 8.93(1H, s), 8.67(1H, dd), 8.14(1H, d), 7.67(2H, d), 7.59(1H, m), 7.46(1H, m), 7.29(2H, m), 7.19(2H, d), 5.23(2H, s); m/z (M+1+) 482.

Sources & evidence

ORD record
ord-8955e33a356241c8ac7df6fb7a755ab8
Source dataset
uspto-grants-2004_12
Patent number
US06828320B2

Reaction notes

Loading…