4-(3-Fluoro-benzyloxy)-phenylamine → HCID 22609835, compound

HRID 2306732Notes

Reaction equation

HRID 2306732 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][O:6][C:7]1[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=1.[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([C:28]3[O:29][C:30]([C:33]([F:36])([F:35])[F:34])=[N:31][N:32]=3)[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:17].[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][O:6][C:7]1[CH:13]=[CH:12][C:10]([NH:11][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[O:29][C:30]([C:33]([F:36])([F:34])[F:35])=[N:31][N:32]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 167753144-(3-Fluoro-benzyloxy)-phenylamineHCID 226097564-Chloro-6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)quinazoline

Product 1

HCID 22609835HCID 22609835, compound

Procedure

The title compound was prepared according to Procedure A from 4-(3-fluoro-benzyloxy)aniline and 4-chloro-6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazoline; δH [2H6]DMSO 11.74(1H, bs), 9.51(1H, s), 8.91(1H, s), 8.66(1H, dd), 8.12(1H, d), 7.65(2H, d), 7.48(1H, m), 7.32(2H, m), 7.19(1H, m), 7.17(2H, d), 5.20(2H, s); m/z (M+1+) 482.

Sources & evidence

ORD record
ord-86e53c6195614f2faf5c39968038d878
Source dataset
uspto-grants-2004_12
Patent number
US06828320B2

Reaction notes

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