5-Amino-1-(2-fluorobenzyl)-1H-indazole → (1-(2-Fluoro-benzyl)-1H-indazol-5-yl)-(6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine

HRID 2306745Notes

Reaction equation

HRID 2306745 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH2:14])=[CH:11][CH:12]=2)[CH:7]=[N:6]1.Cl[C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([C:30]3[O:31][C:32]([C:35]([F:38])([F:37])[F:36])=[N:33][N:34]=3)[CH:28]=2)[N:23]=[CH:22][N:21]=1>>[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]5[O:31][C:32]([C:35]([F:38])([F:36])[F:37])=[N:33][N:34]=5)[CH:28]=4)[N:23]=[CH:22][N:21]=3)=[CH:11][CH:12]=2)[CH:7]=[N:6]1

Participants

3

Reactant 2

HCID 219520555-Amino-1-(2-fluorobenzyl)-1H-indazoleHCID 226097564-Chloro-6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)quinazoline

Product 1

HCID 22609810(1-(2-Fluoro-benzyl)-1H-indazol-5-yl)-(6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine

Procedure

The title compound was prepared according to Procedure A from 1-(2-fluoro-benzyl)-1H-indazol-5-ylamine and 4-chloro-6-(5-trifluoromethyl-1,3,4-oxadiazol-2-yl)-quinazoline; δH [2H6]DMSO 11.79(1H, bs), 9.53(1H, s), 8.89(1H, s), 8.77(1H, dd), 8.21(1H, s), 8.11(1H, m), 8.10(1H, d), 7.84(1H, d), 7.70(1H, dd), 7.37(1H, m), 7.24 (1H, m), 7.18 (2H, m), 5.76(2H, s); m/z (M+1+) 506.

Sources & evidence

ORD record
ord-c9492cbc9b5f4b49b263c69ba8fe577d
Source dataset
uspto-grants-2004_12
Patent number
US06828320B2

Reaction notes

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