1-Methyl-5-(tri-n-butylstannyl)imidazole → (1-Benzyl-1H-indazol-5-yl)-(7-(3-methyl-3H-imidazol-4-yl)quinazolin-4-yl)-amine

HRID 2306749Notes

Reaction equation

HRID 2306749 reaction equation
Cl.[CH2:2]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([NH:18][C:19]3[C:28]4[C:23](=[CH:24][C:25](I)=[CH:26][CH:27]=4)[N:22]=[CH:21][N:20]=3)=[CH:15][CH:16]=2)[CH:11]=[N:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:30][N:31]1[C:35]([Sn](CCCC)(CCCC)CCCC)=[CH:34][N:33]=[CH:32]1>>[CH2:2]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([NH:18][C:19]3[C:28]4[C:23](=[CH:24][C:25]([C:35]5[N:31]([CH3:30])[CH:32]=[N:33][CH:34]=5)=[CH:26][CH:27]=4)[N:22]=[CH:21][N:20]=3)=[CH:15][CH:16]=2)[CH:11]=[N:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 109156511-Methyl-5-(tri-n-butylstannyl)imidazoleHCID 219521701-benzyl-1H-indazol-5-yl(7-iodoquinazolin-4-yl)-amine hydrochloride

Product 1

HCID 22609793(1-Benzyl-1H-indazol-5-yl)-(7-(3-methyl-3H-imidazol-4-yl)quinazolin-4-yl)-amine

Procedure

Prepared according to Procedure B from (1-benzyl-1H-indazol-5-yl)-(7-iodoquinazolin-4-yl)-amine hydrochloride and (3-methyl-3H-imidazol-4-yl) tri-n-butylstannane; δH [2H6]DMSO 11.85(1H, bs), 9.25(1H, s), 9.19(1H, s), 9.02(1H, d), 8.93(1H, s), 8.16(2H, d), 8.06(2H, d), 7.78(1H, d), 7.61(1H, dd), 7.22(5H, m), 5.66(2H, s) 3.92 (3H, s); m/z (M+1+) 432.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f4510a71ec2e44a6a1cf4d43d5d7d76f
Source dataset
uspto-grants-2004_12
Patent number
US06828320B2

Reaction notes

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