2-(Methylsulfonyl)ethanamine → HCID 21951984, compound

HRID 2306753Notes

Reaction equation

[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([C:28]5[O:32][C:31]([CH:33]=O)=[CH:30][CH:29]=5)=[CH:25][CH:26]=4)[N:21]=[CH:20][N:19]=3)=[CH:14][CH:15]=2)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:35][S:36]([CH2:39][CH2:40][NH2:41])(=[O:38])=[O:37]>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([C:28]5[O:32][C:31]([CH2:33][NH:41][CH2:40][CH2:39][S:36]([CH3:35])(=[O:38])=[O:37])=[CH:30][CH:29]=5)=[CH:25][CH:26]=4)[N:21]=[CH:20][N:19]=3)=[CH:14][CH:15]=2)[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamine

HCID 54394484HCID 54394484, compound

Product 1

HCID 21951984HCID 21951984, compound

Procedure

Prepared by an analogous method to Example 10 from 5-[4-(1-benzyl-1H-indazol-5-ylamino)-quinazolin-7-yl]-furan-2-carbaldehyde and 2-methanesulphonylethylamine; δH [2H6] DMSO 9.92(1H, bs), 8.60(1H, d), 8.55(1H, s), 8.25(1H, s), 8.17(1H, s), 8.00(2H, m), 7.72(2H, m), 7.30(6H, m), 6.53 (1H, d), 5.72(2H, s) 4.55 (1H, m), 3.87 (2H, m), 3.35 (2H, m), 3.08 (3H, s), 3.04 (2H, m); m/z (M+1+) 553.

Sources & evidence

ORD record: ord-c7b243ddb0814cf394825f5f66466c78
Source dataset: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06828320B2

Reaction notes

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