Dextromethorphan hydrobromide monohydrate → Dextromethorphan

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Reaction Steps

The salt is prepared by adding silver nitrate (0.96 g, 5.68 mmoles) to a solution of Dextromethorphan hydrobromide (2 g, 5.68 mmoles) in acetonitrile (20 ml). The solution is then stirred at room temperature for 30 minutes. Filtering is then effected to remove silver bromide precipitate. The clear solution is added of ethyl ether (110 ml). A precipitate is formed, that is filtered, washed with ethyl ether and dried under vacuum. The solid obtained at the elemental analysis corresponds to the nitrate salt of Dextromethorphan:

Provenance & Evidence