HCID 22556512, compound → HCID 9886925, compound

HRID 2306800Notes

Reaction equation

HRID 2306800 reaction equation
[C:1]([C:3]1[S:13][C:6]2[NH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:5]=2[CH:4]=1)#[N:2].Cl.[NH2:15][C@@H:16]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:17]([N:19]1[CH2:22][CH:21]([OH:23])[CH2:20]1)=[O:18]>>[CH2:24]([C@H:16]([NH:15][C:10]([C:8]1[NH:7][C:6]2[S:13][C:3]([C:1]#[N:2])=[CH:4][C:5]=2[CH:9]=1)=[O:12])[C:17]([N:19]1[CH2:22][CH:21]([OH:23])[CH2:20]1)=[O:18])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 22556512HCID 22556512, compoundHCID 69687670HCID 69687670, compound

Product 1

HCID 9886925HCID 9886925, compound

Procedure

2-Cyano-6H-thieno[2,3-b]pyrrole-5-carboxylic acid and (2S)-amino-1-(3-hydroxy-azetidin-1-yl)-3-phenyl-propan-1-one hydrochloride were coupled according to Procedure B.

Sources & evidence

ORD record
ord-5bd3fb50afdd4169a4d8db8bdef73e0b
Source dataset
uspto-grants-2004_12
Patent number
US06828343B2

Reaction notes

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