2-Methylserine → HCID 13221873, compound

Temperature

25 °C

In a three neck 1 L round bottom flask under argon, 2-methylserine (35.0 g, 0.2936 mol) was suspended in methanol (300 mL). To this was added 4N HCl/dioxane (85 mL) and the reaction mixture was stirred at 25° C. for 16 h. The reaction mixture had become a clear colorless solution. Dry HCl gas was bubbled into the reaction mixture for 5 min. and the reaction mixture was then stirred at 60° C. for 4 h. It was then cooled and the excess reagent/solvent was removed under reduced pressure at 65° C. to 70° C. to give the desired product (yield 48.2 g, 96%) as an yellow sticky oil.

1. customDry HCl gas was bubbled into the reaction mixture for 5 min.
2. stirringthe reaction mixture was then stirred at 60° C. for 4 h
3. temperatureIt was then cooled
4. customthe excess reagent/solvent was removed under reduced pressure at 65° C. to 70° C.

ORD record

ord-ad56f709d63f40a9b88b339428b142fa

Source dataset

uspto-grants-2004_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06828456B2