Cyclopentanol → HCID 10269921, compound

Participants

Reaction Steps

Following the procedure for the preparation of (5aS*,10bS*)-10-[2-(cyclopentyloxy)phenyl]-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole and substituting cyclohexanol for cyclopentanol while making non-critical variations the title compound was obtained as 278 mg (32%) of a white foam: 1H NMR (400 MHz, CDCl3) δ 7.84 (br s, 1 H), 7.35-7.26 (m, 3 H), 7.15-7.11 (m, 1 H), 7.04-7.01 (m, 2 H), 6.95 (d, J=7.2 Hz, 1 H), 4.08-4.06 (m, 1 H), 3.09-3.07 (m, 2 H), 2.97-2.96 (m, 2 H), 2.85-2.83 (m, 2 H), 2.47-2.37 (m, 2 H), 1.90 (m, 2 H) 1.71 (m, 2 H), 1.51 (m, 2 H), 1.41 (m, 2 H), 1.15 (m, 3 H); HRMS (FAB) calcd for C24H28N2O+H1: 361.2280 found 361.2270.

Provenance & Evidence