HCID 22396916, compound → HCID 69894046, compound

HRID 2307058Notes

Reaction equation

HRID 2307058 reaction equation
Cl.Cl.ClC1C=CC(C2C3C4CCNCCC4NC=3C=CC=2)=CC=1.[Cl:24][C:25]1[CH:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:26]=1[C:32]1[C:33]2[C:34]3[CH2:54][CH2:53][NH:52][CH2:51][CH2:50][C:35]=3[N:36]([CH2:41][CH2:42][O:43][C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:37]=2[CH:38]=[CH:39][CH:40]=1>>[Cl:24][C:25]1[CH:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:26]=1[C:32]1[C:33]2[C@@H:34]3[CH2:54][CH2:53][NH:52][CH2:51][CH2:50][C@@H:35]3[N:36]([CH2:41][CH2:42][O:43][C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:37]=2[CH:38]=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 22396916HCID 22396916, compoundHCID 22609212HCID 22609212, compound

Product 1

HCID 69894046HCID 69894046, compound

Procedure

Following the procedure for the preparation of 10-(4-chlorophenyl)-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole dihydrochloride, making non-critical variations, starting from 10-(2,4-dichlorophenyl)-6-(2-phenoxyethyl)-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole the title compound was prepared: 1H NMR (CD3OD) δ 1.47, 1.55, 2.20, 2.66, 2.90, 3.19, 3.52-3.63, 4.13-4.21, 6.44, 6.50, 6.93, 7.15, 7.25-7.42, 7.57. HRMS (FAB) calcd for C26H26Cl2N2O2 (MH+) 453.1500, found 453.1520.

Sources & evidence

ORD record
ord-bc14ad4ea32440e5a118ac39fcc01a56
Source dataset
uspto-grants-2004_12
Patent number
US06828314B2

Reaction notes

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