2-(3,3,5,5-Tetramethylcyclohexylidene)ethanamine hydrochloride → 2-(3,3,5,5-Tetramethylcyclohexylidene)propanamine hydrochloride

Participants

Reaction Steps

Prepared from nitrile 21 according to the procedure for compound 22 (Example 10, b). Amine hydrochloride 23 obtained as a colorless solid. 1H-NMR: (CDCl3, TMS): 0.92 and 0.93 (total 12H, both s, c-Hex-3,5-CH3); 1.27 (2H, s, c-Hex-4-CH2); 1.89 (3H, s, propanamine-3-CH3); 1.99 and 2.01 (total 4H, both s, c-Hex-2,6-CH2); 3.64 (2H, br s, propanamine-1-CH2) and 8.40 ppm (3H, br s, NH3+).

Provenance & Evidence