HCID 22630139, compound → 2-Methyl-1-(3,3,5,5-tetramethylcyclohexylidene)-2-propanamine hydrochloride

HRID 2307090Notes

Reaction equation

HRID 2307090 reaction equation
[N:1]([C:4]([CH3:17])([CH3:16])[CH:5]=[C:6]1[CH2:11][C:10]([CH3:13])([CH3:12])[CH2:9][C:8]([CH3:15])([CH3:14])[CH2:7]1)=[N+]=[N-].[ClH:18].CC1(C)CC(C)(C)CC(=CC(N)C)C1>>[ClH:18].[CH3:17][C:4]([NH2:1])([CH3:16])[CH:5]=[C:6]1[CH2:7][C:8]([CH3:15])([CH3:14])[CH2:9][C:10]([CH3:13])([CH3:12])[CH2:11]1

Participants

3

Reactant 2

HCID 22630139HCID 22630139, compoundHCID 226301541-(3,3,5,5-Tetramethylcyclohexylidene)-2-propanamine hydrochloride

Product 1

HCID 226301432-Methyl-1-(3,3,5,5-tetramethylcyclohexylidene)-2-propanamine hydrochlorideYield 69%

Procedure

Prepared from azide 30 by the same procedure as for amine 24 (Example 4). Amine hydrochloride 31 obtained as a colorless solid in 69% yield. 1H-NMR (CDCl3, TMS): 0.91 and 0.98 (total 12H, both s, c-Hex-3,5-CH3); 1.26 (2H, s, c-Hex-4-CH2); 1.68 (6H, s, —C(CH3)2N); 1.84 and 2.10 (both 2H, both s, c-Hex-2,6-CH2); 5.15 (1H, s, ═CH—) and 8.5 ppm (3H, br s, NH3+).

Sources & evidence

ORD record
ord-8a89f715150f4acf80b272ea8bc9d046
Source dataset
uspto-grants-2004_12
Patent number
US06828462B2

Reaction notes

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