Methanesulfonyl chloride → HCID 22605405, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-(4-fluorophenyl)-1-diphenylmethyl-3-azetidinol (15) (4.0 g) and N,N-diisopropylethylamine (3.2 mL) in dichloromethane (100 mL) at 0° C. was added, dropwise, methanesulfonyl chloride (125 mL). The mixture was stirred at 0° C. for 18 hrs, then washed (water, brine) and dried (Na2SO4) and concentrated in vacuo. The crude product was recrystallised from hexane to give 3-(4-fluorophenyl)-3-chloro-1-(diphenylmethyl)azetidine (16) (22 g), m.p. 108-109° C. (hexane). Found: C, 75.13; H, 5.46; N, 3.93. C22H19CIFN C, 75.10; H, 5.44; N, 3.98%.

Provenance & Evidence