HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-1-aminopropan-2-ol → (R)-3-(4-(Trifluoromethyl)phenyl)-N-(2-hydroxypropyl)azetidine carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-1-aminopropan-2-ol | HCID 439938 | — |
| Reactant | 3-(4-tert-butylphenyl)-N-(2-propenyl)azetidine-1-carboxamide | HCID 22605403 | — |
| Reactant | 3-(4-(Trifluoromethyl)phenyl)-1-(diphenylmethyl)azetidine | HCID 22605423 | — |
| Solvent | Water | HCID 962 | — |
| Product | (R)-3-(4-(Trifluoromethyl)phenyl)-N-(2-hydroxypropyl)azetidine carboxamide | HCID 9839364 | — |
Reaction Steps
This compound was prepared from compound (32) and (R)-1-amino-2-propanol using the procedure described for compound (12). m.p. 107-108° C. Found: C, 54.78; H, 5.75; N, 9.01. C14H17F3N2O2.0.25 H2O requires C, 54.81; H. 5.71, N, 9.13%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831078B1 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-f64ebf06b614473fbb72850a7998431c |
| Source note | uspto-grants-2004_12 |