Fuming sulfuric acid → HCID 178524662, compound

Participants

Reaction Conditions

Reaction Steps

2-Hydroxynicotinic acid (27 Kg, 194.2 mol) was added portionwise to 30% oleum (58.1 Kg) at 50° C. over 1 hour. This caused an exotherm to 82° C. The reaction mixture was heated further to 140° C. After maintaining this temperature for 12 hours the reactor contents were cooled to 15° C. and filtered. The filter cake was then re-slurried with acetone (33 Kg) at room temperature, filtered and dried to afford the title compound, 35.3 Kg, as a white solid.

Provenance & Evidence