1-Nicotinoyl-3-phenyl-2-pyrazoline → 1-Nicotinoyl-3-phenyl-2-pyrazoline methanesulfonate

HRID 2307262Notes

Reaction equation

HRID 2307262 reaction equation
[C:1]([N:9]1[CH2:13][CH2:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.C(O)C.[CH3:23][S:24]([OH:27])(=[O:26])=[O:25]>C(O)C>[CH3:23][S:24]([OH:27])(=[O:26])=[O:25].[C:1]([N:9]1[CH2:13][CH2:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 98196571-Nicotinoyl-3-phenyl-2-pyrazolineHCID 86653870Methanesulfonic acid ethanol

Product 1

HCID 98196561-Nicotinoyl-3-phenyl-2-pyrazoline methanesulfonate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Nicotinoyl-3-phenyl-2-pyrazoline (0.1 g) synthesized in Example 3 was dissolved in ethanol (5 ml). Thereto was added a 1 N methanesulfonic acid ethanol solution (0.6 ml) with ice-cooling. The resulting crystals were collected by filtration, washed with ether and dried to obtain 0.1 g of a title compound as white crystals.

Workup

  1. temperaturecooling
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-f2e07d8bcefb4b849a2f7b581c2b7a75
Source dataset
uspto-grants-2004_12
Patent number
US06831083B2

Reaction notes

Loading…