Dichloromethane → HCID 60094104, compound

Participants

Reaction Steps

(S)-((3R)-5-Oxomorpholin-3-yl)(phenyl)methyl 4-nitrobenzoate (Preparation 7, 1.2 g) is treated with dichloromethane (10 mL), ethanol (30 mL) and potassium carbonate (1.0 g). After 2 h, the reaction mixture is filtered and the filtered solid is triturated with ethanol-dichloromethane (3:1 v:v, 3×30 mL). The filtrates are combined and concentrated under reduced pressure. The resulting residue is adsorbed onto silica gel and purified by flash column chromatography (methanol/CH2Cl2, 1-6%) to afford 0.61 g of the title compound. Physical characteristics. 1H NMR (400 MHz, DMSO-d6) δ 7.55, 7.4-7.2, 5.65, 4.61, 3.92, 3.9-3.8, 3.65-3.55, 3.44.

Provenance & Evidence