HCID 69860165, compound → HCID 60094113, compound

HRID 2307296Notes

Reaction equation

HRID 2307296 reaction equation
Cl[CH2:2][C:3]1[S:18][C:6]2[N:7]([CH2:15][CH2:16][CH3:17])[CH:8]=[C:9]([C:12]([NH2:14])=[O:13])[C:10](=[O:11])[C:5]=2[CH:4]=1.[ClH:19].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][C@@H:21]1[C@H:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[OH:27]>>[Cl:19][C:31]1[CH:32]=[CH:33][C:28]([CH2:26][NH:14][C:12]([C:9]2[C:10](=[O:11])[C:5]3[CH:4]=[C:3]([CH2:2][N:20]4[CH2:25][CH2:24][O:23][CH2:22][C@@H:21]4[C@@H:26]([OH:27])[C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[S:18][C:6]=3[N:7]([CH2:15][CH2:16][CH3:17])[CH:8]=2)=[O:13])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 69860165HCID 69860165, compoundHCID 86759574HCID 86759574, compound

Product 1

HCID 60094113HCID 60094113, compound

Procedure

Analogous to the procedures described in Example 15, N-(4-chlorobenzyl)-2-(chloromethyl-7-propyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide (Preparation 13) is treated with (S)-(3R)-morpholin-3-yl(phenyl)methanol hydrochloride (Preparation 9) to afford the title compound.

Sources & evidence

ORD record
ord-145085b877624ba19ae23163ed7f55a0
Source dataset
uspto-grants-2004_12
Patent number
US06831081B2

Reaction notes

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