Potassium Carbonate → HCID 22605718, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(4-chlorobenzyl)-2-((2-chloro-5-(morpholin-4-ylmethyl)thien-3-yl)carbonyl)-3-((2-morpholin-4-ylethyl)amino)acrylamide (Preparation 6, 4.3 g) and K2CO3 (1.6 g) in DMF (75 mL) is stirred at 100° C. for 5 h. The mixture is allowed to cool to room temperature and is concentrated in vacuo. The crude product is triturated with EtOAc and filtered to afford 1.4 g of the title compound as a yellow solid Physical characteristics. 1H NMR (300 MHz, DMSO-d6) δ 10.57, 8.71, 7.42-7.32, 4.55, 4.37, 3.74, 3.59, 3.50, 2.73, 2.44; MS (ESI+) m/z 531 (M+H)+.

Provenance & Evidence