HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylpyrazole → [4-(4-Methyl-pyrazol-1-yl)-2-trifluoromethyl-phenyl]-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylpyrazole | HCID 3406 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 9799697 | HCID 9799697 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [4-(4-Methyl-pyrazol-1-yl)-2-trifluoromethyl-phenyl]-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone | HCID 9910880 | 50.4% |
Reaction Steps
In the manner of Example 2, employing (4-fluoro-2-trifluoromethyl-phenyl)(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (0.8 g), 60% sodium hydride in oil (0.15 g), 4-methylpyrazole (0.20 g) and dimethylformamide (25 ml), the product (0.47 g) was obtained as a colorless amorphous solid, MS, m/z: 437.3 (M+H)+, 873.2 (2M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831079B1 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-5c420e4872504565b22bbd13d5b0368a |
| Source note | uspto-grants-2004_12 |