Sodium Hydroxide → [2-(5-chlorothiophen-2-yl)-1H-benzimidazol-5-yl]acetic acid

Participants

Reaction Steps

3.2 34.7 ml of aqueous 1 N sodium hydroxide solution are added to a solution of 10.1 g (about 20.5 mmol) of ethyl [2-(5-chlorothiophen-2-yl)-1H-benzimidazol-5-yl]acetate in 70 ml of methanol, and the mixture is stirred at room temperature for 3 days. The reaction mixture is evaporated, and the residue is taken up in 25 ml of water. A pH of 4.5 is set by addition of conc. hydrochloric acid. The resultant precipitate is filtered off, washed with water and dried, giving [2-(5-chlorothiophen-2-yl)-1H-benzimidazol-5-yl]acetic acid as a yellowish solid; ESI 293.

Provenance & Evidence