Methylhydrazine → HCID 3953327, compound

HRID 2307350Notes

Reaction equation

HRID 2307350 reaction equation
[CH:1]([C:3]([C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1)=[CH:4]O)=O.[CH3:15][NH:16][NH2:17]>C(O)C>[CH3:15][N:16]1[CH:4]=[C:3]([C:6]2[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=2)[CH:1]=[N:17]1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 3610278HCID 3610278, compound

Product 1

HCID 3953327HCID 3953327, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 6-(1-formyl-2-hydroxyvinyl)pyridine-3-carboxylic acid (1.93 g) Eastman Chemicals) in absolute ethanol (50 ml) and methylhydrazine (0.50 g) was stirred for 18 hours at room temperature. The reaction mixture was filtered to give the product (1.30 g). The filtrate was evaporated to give a solid which was recrystallized from ethyl acetate to give an analytical sample of the title compound (0.55 g), m.p. 262-264° C.

Workup

  1. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-65112631dd2045e2b8b6f59a5b20d5d0
Source dataset
uspto-grants-2004_12
Patent number
US06831079B1

Reaction notes

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