反应详情

14.5 5 ml of aqueous 1 N sodium hydroxide solution are added to a solution of 1.04 g (2.81 mmol) of methyl [2-(5-chlorothiophen-2-yl)-1H-benzimidazole-5-sulfonyl]acetate in 50 ml of methanol, and the mixture is stirred at room temperature for 3 days. The reaction mixture is evaporated, and the residue is taken up in water. A pH of 2 is set by addition of conc. hydrochloric acid. The resultant precipitate is filtered off, washed with water and dried, giving [2-(5-chlorothiophen-2-yl)-1H-benzimidazole-5-sulfonyl]acetic acid as a brownish solid; ESI 357.

1. customThe reaction mixture is evaporated
2. additionA pH of 2 is set by addition of conc. hydrochloric acid
3. filtrationThe resultant precipitate is filtered off
4. washwashed with water
5. customdried