Sodium Hydroxide → HCID 178526048, compound

HRID 230737Notes

Reaction equation

HRID 230737 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[S:8][C:7]([C:9]2[NH:13][C:12]3[CH:14]=[CH:15][C:16]([S:18]([CH2:21][C:22]([O:24]C)=[O:23])(=[O:20])=[O:19])=[CH:17][C:11]=3[N:10]=2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[S:8][C:7]([C:9]2[NH:13][C:12]3[CH:14]=[CH:15][C:16]([S:18]([CH2:21][C:22]([OH:24])=[O:23])(=[O:19])=[O:20])=[CH:17][C:11]=3[N:10]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178501896HCID 178501896, compound

Product 1

HCID 178526048HCID 178526048, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

14.5 5 ml of aqueous 1 N sodium hydroxide solution are added to a solution of 1.04 g (2.81 mmol) of methyl [2-(5-chlorothiophen-2-yl)-1H-benzimidazole-5-sulfonyl]acetate in 50 ml of methanol, and the mixture is stirred at room temperature for 3 days. The reaction mixture is evaporated, and the residue is taken up in water. A pH of 2 is set by addition of conc. hydrochloric acid. The resultant precipitate is filtered off, washed with water and dried, giving [2-(5-chlorothiophen-2-yl)-1H-benzimidazole-5-sulfonyl]acetic acid as a brownish solid; ESI 357.

Workup

  1. customThe reaction mixture is evaporated
  2. additionA pH of 2 is set by addition of conc. hydrochloric acid
  3. filtrationThe resultant precipitate is filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-6ff62535f9b14c429fbffeb51fbd6ff6
Source dataset
uspto-grants-2009_07
Patent number
US07566789B2

Reaction notes

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