tert-Butoxy bis(dimethylamino)methane → HCID 69844398, compound

HRID 2307394Notes

Reaction equation

HRID 2307394 reaction equation
[N:1]1[N:10]2[C:4]([CH2:5][N:6]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[CH:19][CH:18]=3)=[O:16])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9]2)=[CH:3][CH:2]=1.C(O[CH:31](N(C)C)[N:32]([CH3:34])[CH3:33])(C)(C)C>ClCCl>[N:1]1[N:10]2[C:4]([CH2:5][N:6]([C:15]([C:17]3[CH:18]=[CH:19][C:20]([C:23](=[O:25])[CH:24]=[CH:31][N:32]([CH3:34])[CH3:33])=[CH:21][CH:22]=3)=[O:16])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9]2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 9905595HCID 9905595, compound

Product 1

HCID 69844398HCID 69844398, compoundYield 76.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 1-[4-(4H,10H-pyrazolo[5,1-c][1,4]benzodiazepine-5-carbonyl) phenyl]ethanone (0.73 g), tert-butoxybis-[dimethylamino]methane (0.964 g) in dichloromethane (10 ml) was stirred at room temperature for 2 days. The mixture is concentrated in vacuo and the residue crystallized from dichloromethane-hexane to give 0.65 g of the title compound as yellow crystals, m.p. 225-230° C.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. customthe residue crystallized from dichloromethane-hexane

Sources & evidence

ORD record
ord-2d3e5b77e71f4f88a5ccc4bff6156091
Source dataset
uspto-grants-2004_12
Patent number
US06831079B1

Reaction notes

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