2,2,2-Trifluoro-1-(3-morpholin-4-yl-phenyl)-ethanone oxime → 2,2,2-Trifluoro-1-(3-morpholin-4-yl-phenyl)-ethylamine

Participants

Reaction Steps

A suspension of 2,2,2-trifluoro-1-(3-morpholin-4-yl-phenyl)-ethanone oxime (1.37 g) and Ra—Ni (1 mL) in a mixture of 3 ml of 30% ammonium hydroxide and 15 mL of MeOH was hydrogenated at 60 psi for 16 hours. The crude reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to give the title compound as an oil (1.3 g).

Provenance & Evidence