HCID 69919428, compound → HCID 69852259, compound

Participants

Reaction Steps

The mixture of (S)-(1-{3-[2-(tert-butoxycarbonylaminomethyl)-morpholin-4-yl]-phenyl}-ethyl)-carbamic acid benzyl ester (600 mg, 1.3 mmol), palladium on C (10 wt %) (300 mg), and methanol (10 ml) was put onto hydrogenator and shaken at 50 psi of hydrogen for 2 days and one night. The mixture was filtered through Celite pad and washed with methanol. The filtrate was concentrated under vacuum. The sticky oil (89% yield) was used for next step without purification.

Provenance & Evidence