Hydrochloric Acid → HCID 59095725, compound

Participants

Reaction Steps

A solution of (S)-{1-[3-(4-methylpiperazin-1-yl)phenyl]ethyl}carbamic acid tert-butyl ester (3.4 g, 10.7 mmol) and hydrochloric acid (4N, 11 ml) in dioxane (40 ml) was stirred at 40° C. for 5 hours. The reaction mixture was concentrated under vacuum, dissolved into dichloromethane (100 mL), and based with SN NaOH. The organic layer was washed with brine (2×100 ml), dried over sodium sulfate and concentrated under vacuum to afford the title compound as an oil (1.90 g, 81% yield) which was used for next step without further purification.

Provenance & Evidence