Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | HCID 86589154 | HCID 86589154 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 67550430 | HCID 67550430 | — |
Reaction Steps
To a solution of (S)-3-phenyl-N-[1-(3-trifluoromethanesulfonyloxy-phenyl)-ethyl]acrylamide (50 mg) in DME (0.5 mL) at room temperature was added Pd2(dba)3 (29 mg), potassium phosphate (37 mg), morpholine (0.02 mL), and the resulting suspension was heated at 80° C. for 15 hours. The solvent was removed in vacuo, and the residue was purified by preparative HPLC to afford the title compound as the trifluoacetic acid salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06831080B2 |
|---|
| Source dataset | uspto-grants-2004_12 |
|---|
| ORD ID | ord-7bc78ec4c08243efb94d1f83adc5c008 |
|---|
| Source note | uspto-grants-2004_12 |
|---|
