HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (+/-)-3-(2-fluoro-phenyl)-N-[2,2,2-trifluoro-1-(3-morpholin-4-yl-phenyl)ethyl]acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(2-Fluorophenyl)prop-2-enoic acid | HCID 67977 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2,2,2-Trifluoro-1-(3-morpholin-4-yl-phenyl)-ethylamine | HCID 22605494 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (+/-)-3-(2-fluoro-phenyl)-N-[2,2,2-trifluoro-1-(3-morpholin-4-yl-phenyl)ethyl]acrylamide | HCID 69918775 | — |
Reaction Steps
A mixture of 2-fluorocinnamic acid (33 mg), 2,2,2-trifluoro-1-(3-morpholin-4-yl-phenyl)-ethylamine, Preparation 23 (52 mg), DMAP (24 mg), EDC.HCl (80 mg), and Et3N (80 mg) in CH2Cl2 (4 mL) was stirred for 16 hours. Purification by flash chromatography over silica gel (elution with 50% ethyl acetate in hexane) gave 65 mg of the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831080B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-1b59bbd644ea45d0b39c70a6eabe3227 |
| Source note | uspto-grants-2004_12 |