HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67550666, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 20744332 | HCID 20744332 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67550666 | HCID 67550666 | — |
Reaction Steps
A mixture of 4-fluorocinnamic acid (1 mmol), (±)-7-(1-aminoethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid methyl ester, Preparation 10 (280 mg, 1.2 mmol), EDC hydrochloride (387 mg, 2 mmol), DMAP (122 mg, 1 mmol), and triethylamine (404 mg, 4 mmol) in CH2Cl2 (8 mL) was stirred at room temperature for 16 hours. The reaction mixture was directly subjected to purification by flash column chromatography on silica gel eluted with EtOAc/hexane (50%) to provide the title compound (295 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831080B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-769c35533749475fa95f2da676679d2d |
| Source note | uspto-grants-2004_12 |