Formic Acid → HCID 69919825, compound

HRID 2307472Notes

Reaction equation

HRID 2307472 reaction equation
[C:1]1([CH:7]=[CH:8][C:9]([NH:11][CH:12]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[NH:20][CH2:19][CH2:18][CH2:17]3)[CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+].[CH:26](O)=O>>[CH3:26][N:20]1[C:21]2[C:16](=[CH:15][C:14]([CH:12]([NH:11][C:9](=[O:10])[CH:8]=[CH:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH3:13])=[CH:23][CH:22]=2)[CH2:17][CH2:18][CH2:19]1

Participants

4

Reactant 3

HCID 284Formic AcidHCID 4311764Sodium borohydrideHCID 69850577HCID 69850577, compound

Product 1

HCID 69919825HCID 69919825, compound

Procedure

Example 256 was prepared from 3-phenyl-N-[1-(1,2,3,4-tetrahydro-quinolin-6-yl)-ethyl]-acrylamide by treatment with formic acid and sodium borohydride following the general procedures described by Gribble et. al. (J. Amer. Chem. Soc., 1974, 7812).

Sources & evidence

ORD record
ord-0b3d60345892444b8cea6a7b89b10d09
Source dataset
uspto-grants-2004_12
Patent number
US06831080B2

Reaction notes

Loading…