1,2-Dichloroethane → HCID 69859654, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(2-fluoro-phenyl)-acrylic acid (0.083 mmol), (S)-1-(3-pyridin-3-yl-phenyl)ethylamine (12.7 mg, 0.064 mmol), EDC (18.4 mg, 0.096 mmol), HOBT (13 mg, 0.096 mmol), DMF (2 mL) and diisopropylethylamine (33 μL, 0.192 mmol) was stirred at 23° C., 18 hours. The residue was purified by preparative HPLC (Primeshere C18-HC 21.2×100 mm; (5 mM NH4OAc) 0-100% gradient over 5 minutes 20 mL/min flow rate) to afford the title product.

Provenance & Evidence