1,2-Dichloroethane → HCID 69917136, compound

Participants

Reaction Steps

A solution of 4-fluorocinnamic acid (17 mg, 0.1 mmol), (S)-1-[3-(4-methylpiperazin-1-yl)-phenyl]ethylamine (preparation 42, 24 mg, 0.11 mmol), EDC (28 mg, 0.15 mmol), DMAP (12 mg, 0.1 mmol) and triethylamine (40 mg, 0.4 mmol) in dichloromethane (2 ml) was stirred overnight. The reaction mixture was purified by fresh chromatography over silica gel with 5% methanol in dichloromethane to give the title compound as a solid (27 mg 74% yield).

Provenance & Evidence