p-Fluoronitrobenzene → HCID 131727547, compound

Participants

Reaction Steps

To a solution of tert-butyl 1H-pyrrolo[3,2-c]pyridine-6-carboxylate (120 mg, 0.55 mmol) in DMF (3 mL) at rt, was added NaH (60% in mineral oil, 26.4 mg, 0.66 mmol). The mixture was stirred for 10 min and 4-fluoronitrobenzene (155 mg, 1.1 mmol) was added to the reaction. The resulting mixture was stirred at rt for 1 h. The reaction was quenched with sat. aq. sodium citrate solution, extracted with EtOAc and dried over MgSO4. The product was purified by flash column chromatography (SiO2, 25% EtOAc/CH2Cl2) to give a yellow solid (137 mg, 73%).

Provenance & Evidence