3,4-Bis(benzoyloxymethyl)benzyl bromide → Ethyl 3'-[3,4-bis(benzoyloxymethyl)benzyloxy]biphenyl-3-carboxylate

HRID 2307545Notes

Reaction equation

HRID 2307545 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:19]([O:27][CH2:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[CH2:37][O:38][C:39](=[O:46])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH2:32]Br)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(OCC1(C([O-])=O)C(COC(=O)C2C=CC=CC=2)=CC=C(C2C=CC=CC=2)C1OCC1C=CC=CC=1)(=O)C1C=CC=CC=1>>[C:19]([O:27][CH2:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[CH2:37][O:38][C:39](=[O:46])[C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)[CH2:32][O:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1)(=[O:26])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 223456183,4-Bis(benzoyloxymethyl)benzyl bromideHCID 226068863'-Hydroxy-biphenyl-3-carboxylic acid ethyl esterHCID 1317246863,4-Bis(benzoyloxymethyl)benzyloxylbiphenyl-3-carboxylate

Product 1

HCID 22606919Ethyl 3'-[3,4-bis(benzoyloxymethyl)benzyloxy]biphenyl-3-carboxylate

Procedure

In a manner similar to that of Example 1(i), by reaction of 1 g (4.1 mmol) of ethyl 3′-hydroxybiphenyl-3-carboxylate with 1.98 g (4.5 mmol) of 3,4-bis(benzoyloxymethyl)benzyl bromide, 2.1 g (85%) of ethyl 3′-[3,4-bis(benzoyloxymethyl)benzyloxylbiphenyl-3-carboxylate are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-5abb36a3eb864159880f263ffa46a65b
Source dataset
uspto-grants-2004_12
Patent number
US06831106B1

Reaction notes

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