Tetrahydrofuran → HCID 22606928, compound

Participants

Reaction Steps

130 mg (0.3 mmol) of methyl 3′-(3,4-bis-hydroxymethyl-benzylsulphanyl)-2-methylbiphenyl-4-carboxylate are dissolved in 10 mL of anhydrous THF and 0.7 mL (2 mmol) of an ethylmagnesium bromide solution (3M) are then added. The reaction medium is stirred for 1 h and then treated with ammonium chloride solution. After extraction with ethyl acetate, the organic phases are combined, dried and concentrated under reduced pressure. The residue is purified by chromatography on a column of silica. A colourless oil is obtained (m=105 mg, Y=81%).

Provenance & Evidence