Potassium Carbonate → Methyl 3'-hydroxy-2'-methylbiphenyl-4-carboxylate

Participants

Reaction Steps

In a manner similar to that of Example 11(d), by reaction of 3.3 g (16.7 mmol) of 3-methoxymethoxy-2-methylbenzene-1-boronic acid (described in Example 11(c)) with 3 g (13.9 mmol) of ethyl 4-iodobenzoate, 16.7 mL of 2.0M potassium carbonate solution and 800 mg (0.69 mmol) of tetrakis(triphenylphosphine)palladium, followed by deprotection in methanol, the desired product is obtained in the form of a colourless oil (m=3.07 g; Y=77%).

Provenance & Evidence